Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.
Identifieur interne : 000A03 ( Main/Exploration ); précédent : 000A02; suivant : 000A04Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins.
Auteurs : Hélène Malet ; Kaiyin Liu [France] ; Majida El Bakkouri [France] ; Sze Wah Samuel Chan [France] ; Grégory Effantin [France] ; Maria Bacia-Verloop [France] ; Walid A. Houry ; Irina Gutsche [France]Source :
Abstract
A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries-the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI-is reconstructed by cryo-electron microscopy to 11 Å resolution. Combined with a 7.5 Å resolution reconstruction of the minimal complex between LdcI and the LdcI-binding domain of RavA, and the previously solved crystal structures of the individual components, this work enables to build a reliable pseudoatomic model of this unusual architecture and to identify conformational rearrangements and specific elements essential for complex formation. The design of the cage created via lateral interactions between five RavA rings is unique for the diverse AAA+ ATPase superfamily.
Url:
Affiliations:
- France
- Auvergne-Rhône-Alpes, Grand Est, Lorraine (région), Rhône-Alpes
- Grenoble, Metz, Nancy
- Université Joseph Fourier, Université de Grenoble, Université de Lorraine
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000F99
- to stream Hal, to step Curation: 000F99
- to stream Hal, to step Checkpoint: 000940
- to stream Main, to step Merge: 000A05
- to stream Main, to step Curation: 000A03
Le document en format XML
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DEN/DM2S/SEMT</orgName><desc><address><addrLine>CEA Saclay - 91191 Gif-Sur-Yvette</addrLine><country key="FR"></country></address></desc></org></tutelle><tutelle name="UMR5075" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Bacia Verloop, Maria" sort="Bacia Verloop, Maria" uniqKey="Bacia Verloop M" first="Maria" last="Bacia-Verloop">Maria Bacia-Verloop</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-576" status="VALID"><orgName>Institut de biologie structurale</orgName><orgName type="acronym">IBS - UMR 5075</orgName><desc><address><addrLine>Institut de Biologie Structurale Jean-Pierre Ebel, CEA-CNRS-UJF, 41, rue Jules Horowitz, F-38027 Grenoble, Cedex 1</addrLine><country key="FR"></country></address><ref type="url">http://www.ibs.fr/</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation><relation name="DSV/IBS" active="#struct-300016" type="direct"></relation><relation name="UMR5075" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><date type="end">2015-12-31</date><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle><tutelle name="DSV/IBS" active="#struct-300016" type="direct"><org type="institution" xml:id="struct-300016" status="VALID"><orgName>CEA</orgName><orgName type="acronym">CEA - DEN/DM2S/SEMT</orgName><desc><address><addrLine>CEA Saclay - 91191 Gif-Sur-Yvette</addrLine><country key="FR"></country></address></desc></org></tutelle><tutelle name="UMR5075" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author><author><name sortKey="Houry, Walid A" sort="Houry, Walid A" uniqKey="Houry W" first="Walid A" last="Houry">Walid A. Houry</name></author><author><name sortKey="Gutsche, Irina" sort="Gutsche, Irina" uniqKey="Gutsche I" first="Irina" last="Gutsche">Irina Gutsche</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-89577" status="INCOMING"><orgName>Unit of Virus Host Cell Interaction</orgName><orgName type="acronym">UMR 5233</orgName><desc><address><addrLine>6 rue Jules Horowitz, B.P. 181 38042 Grenoble cedex 9, France</addrLine><country key="FR"></country></address><ref type="url">http://www.uvhci.fr</ref></desc><listRelation><relation active="#struct-51016" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD"><orgName>Université Joseph Fourier</orgName><orgName type="acronym">UJF</orgName><date type="end">2015-12-31</date><desc><address><addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine><country key="FR"></country></address><ref type="url">http://www.ujf-grenoble.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="university">Université Joseph Fourier</orgName><orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries-the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI-is reconstructed by cryo-electron microscopy to 11 Å resolution. Combined with a 7.5 Å resolution reconstruction of the minimal complex between LdcI and the LdcI-binding domain of RavA, and the previously solved crystal structures of the individual components, this work enables to build a reliable pseudoatomic model of this unusual architecture and to identify conformational rearrangements and specific elements essential for complex formation. The design of the cage created via lateral interactions between five RavA rings is unique for the diverse AAA+ ATPase superfamily.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Lorraine (région)</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Metz</li><li>Nancy</li></settlement><orgName><li>Université Joseph Fourier</li><li>Université de Grenoble</li><li>Université de Lorraine</li></orgName></list><tree><noCountry><name sortKey="Houry, Walid A" sort="Houry, Walid A" uniqKey="Houry W" first="Walid A" last="Houry">Walid A. Houry</name><name sortKey="Malet, Helene" sort="Malet, Helene" uniqKey="Malet H" first="Hélène" last="Malet">Hélène Malet</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Liu, Kaiyin" sort="Liu, Kaiyin" uniqKey="Liu K" first="Kaiyin" last="Liu">Kaiyin Liu</name></region><name sortKey="Bacia Verloop, Maria" sort="Bacia Verloop, Maria" uniqKey="Bacia Verloop M" first="Maria" last="Bacia-Verloop">Maria Bacia-Verloop</name><name sortKey="Chan, Sze Wah Samuel" sort="Chan, Sze Wah Samuel" uniqKey="Chan S" first="Sze Wah Samuel" last="Chan">Sze Wah Samuel Chan</name><name sortKey="Effantin, Gregory" sort="Effantin, Gregory" uniqKey="Effantin G" first="Grégory" last="Effantin">Grégory Effantin</name><name sortKey="El Bakkouri, Majida" sort="El Bakkouri, Majida" uniqKey="El Bakkouri M" first="Majida" last="El Bakkouri">Majida El Bakkouri</name><name sortKey="Gutsche, Irina" sort="Gutsche, Irina" uniqKey="Gutsche I" first="Irina" last="Gutsche">Irina Gutsche</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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